Neuronal innervation of the intestinal crypt

Mucosal damage is a key feature of inflammatory bowel diseases (IBD) and healing the mucosa an endpoint IBD treatment that often difficult to achieve. Autonomic neurons parasympathetic sympathetic nervous system may influence intestinal epithelial cell growth modulating innervation could for reason serve as interesting therapeutic option improve mucosal healing. Understanding biological processes triggered by nonspecific specific adrenergic cholinergic receptor activation importance. At present, with rising technological advances, bioelectronic neuromodulation modality has gained momentum. We discuss current view on state-of-the-art crypt its impact differentiation. Furthermore, we outline technology review relevance wound processes.